今日はまる24時間日当直です。今まで何もありません。
寒かったですね。朝は家々の屋根にもうっすら雪が積もっていました。午後から雲がなくなりその分寒さが増しました。
今もどんどん気温が下がっている感じです。
O先生の二本目正式にacceptということです
何はともあれよかったです
The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells
Abstract
Calcium ion is one of the most important second messengers of cellular signal transduction including hypoxia-elicited signals. In this study, we investigated the effects of the L-type calcium channel blockers such as nifedipine, efonidipine cilnidipine, diltiazem, and verapamil, on the activity of hypoxia-inducible factor-1 (HIF-1), a key transcription factor in control of hypoxia-induced gene expression. Using the lung carcinoma cell line A549 cells, human aortic smooth muscle cells, and human umbilical vein endothelial cells, we demonstrated that the cilnidipine exclusively suppressed HIF-1 activity and the expressions of downstream genes in a cell-type specific manner. We also demonstrated that cilnidipine blocked the synthesis of the HIF-1α protein not by affecting activity of the intracellular hypoxia-sensing element prolyl hydroxylases but inhibiting activity of Akt and mitogen-activated protein kinase and that the inhibition is not dependent on the effect on calcium homeostasis.
European Journal of Pharmacology
カルシウムブロッカーの作用を肺胞上皮、血管内皮、血管平滑筋で見たという報告です
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