Archive for the ‘論文’ tag
“Ten for the Next Ten” by Bono
今朝も寒かったですね。職場の空調の調子が悪く朝のうち一時間くらい結構寒かったです。
東山は日の出が遅く最近では職場に到着したところでようやく太陽が山の端に顔を出します。
この二つの論文はけっこうおもしろかった。
J Am Chem Soc. 2009 Dec 30. [Epub ahead of print]
PLoS Comput Biol. 2009 Dec;5(12):e1000619. Epub 2009 Dec 24.
これにもびっくり
J Clin Invest. doi:10.1172/JCI39778.
院生の田中先生の論文が二つともMEDLINEに入りました。
New York TimeにBonoの論説が載っていました。
Ten for the Next Tenということで次の10年注目の10項目をBonoが解説するというものです。
なぜか
A Person (Dr. William Li) and a Word (Angiogenesis)
Angiogenesis is the process by which new blood vessels grow. This is good — except when it’s very bad, as in the case of cancerous tumors. Blood vessels are their supply lines. Dr. William Li of the Angiogenesis Foundation has called research in this realm the “first medical revolution of the 21st century,” and he should know. (I shouldn’t, given my lack of a medical pedigree, but I learned about it from my bandmate the Edge, who supports Dr. Li’s foundation.) Work on angiogenesis inhibitors is at the vanguard. In a world worrying about whether it can afford health care, advances in prevention are at a premium.
Factoid: Cancers start as tiny nests of malignant cells that do not enlarge until they recruit new vessels to deliver oxygen and nutrients; then a cancer can expand 16,000 times in only two weeks.
こんなのも入っています。解ってるのかな本当に。
NYTではBonoは
Bono, the lead singer of the band U2 and a founder of the advocacy group ONE and (Product)RED, is a contributing columnist for The Times.
こんな風に紹介されていました。
論文が通りました
大学院生の田中先生の論文が”American Journal of Physiology-Regulatory, Integrative and Comparative Physiology”誌に通りました。
reviewerのコメントも三行ずつしかなかったので通ることはわかっていたのですがなんで三週間も待たされたのかよくわかっていません。年を越えたら申し訳ないと思ったのでしょう。この時期に返事があるのは結構頻度が高いような気がします。
低酸素誘導性遺伝子応答に温度が及ぼす影響をin vitro, in vivoで解析したものです。これは全く今までなかった観点です。良く引用される論文になりh-indexを上げてくれる論文になると思います。
よかったです。
Abstract
The transcription factor hypoxia-inducible factor 1 (HIF-1) plays an essential role in regulating gene expression in response to hypoxia/ischemia. Ischemia makes the tissue not only to be hypoxic but also to be hypothermic because of the hypoperfusion under certain circumstances. On the other hand, the induced hypothermia is one of the most common therapeutic modalities to extend tolerance to hypoxia. Although hypoxia elicits a variety of cellular and systemic responses at different organizational levels in the body, little is known about how hypoxia-induced responses are affected by low temperature. We examined the influence of mild hypothermic conditions (28-32 ˚C) on HIF-1 in both in vitro and in vivo settings. In vitro experiments adopting cultured cells elucidated that hypoxia-induced HIF-1 activation was resistant to 4h-exposure to the low temperature. In contrast, exposure to the low temperature as long as 24 h suppressed HIF-1 activation and the subsequent up-regulation of HIF-1 target genes such as VEGF or GLUT-1. HIF-1α protein stability in the cell was not affected by hypothermic treatment. Furthermore, intracelluar ATP content was reduced under 1% O2 conditions but was not largely affected by hypothermic treatment. The evidence indicate that reduction of oxygen consumption is not largely involved in suppression of HIF-1. In addition, we demonstrated that HIF-1 DNA binding activity and HIF-1-depenedent gene expressions induced under 10% O2 atmosphere in mice brain were not influenced by treatment under 3 h-hypothermic temperature but inhibited under 5 h-treatment. On the other hand, we indicated that warming ischemic legs of mice for 24 h preserved HIF-1 activity. Here we describe first time that persisting low temperature significantly reduced HIFα neosynthesis under hypoxic conditions, leading to decrease in gene expression for adaptation to hypoxia in both in vitro and in vivo settings.
Keywords;
hypoxia, hypothermia, hypoxia-inducible factor 1, ischemia
技あり
PNASから
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
PNAS published online before print October 1, 2009, doi:10.1073/pnas.0909353106
これはすごいのでは
しかし、本当に微妙ないい所に眼をつけるな〜
