hypoxia research::blog

今朝も寒かったですね。職場の空調の調子が悪く朝のうち一時間くらい結構寒かったです。

東山は日の出が遅く最近では職場に到着したところでようやく太陽が山の端に顔を出します。

この二つの論文はけっこうおもしろかった。

Inhibition of Hypoxia Inducible Factor 1-Transcription Coactivator Interaction by a Hydrogen Bond Surrogate alpha-Helix.

J Am Chem Soc. 2009 Dec 30. [Epub ahead of print]

Bistability of Mitochondrial Respiration Underlies Paradoxical Reactive Oxygen Species Generation Induced by Anoxia

PLoS Comput Biol. 2009 Dec;5(12):e1000619. Epub 2009 Dec 24.

これにもびっくり

Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

J Clin Invest. doi:10.1172/JCI39778.

院生の田中先生の論文が二つともMEDLINEに入りました。

Persisting mild hypothermia suppresses hypoxia-inducible factor 1{alpha} protein synthesis and HIF-1-mediated gene expression.

The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible factor 1 activation and suppresses the glucose metabolism in macrophages.

New York TimeにBonoの論説が載っていました。

Ten for the Next Tenということで次の10年注目の10項目をBonoが解説するというものです。
なぜか

A Person (Dr. William Li) and a Word (Angiogenesis)

Angiogenesis is the process by which new blood vessels grow. This is good — except when it’s very bad, as in the case of cancerous tumors. Blood vessels are their supply lines. Dr. William Li of the Angiogenesis Foundation has called research in this realm the “first medical revolution of the 21st century,” and he should know. (I shouldn’t, given my lack of a medical pedigree, but I learned about it from my bandmate the Edge, who supports Dr. Li’s foundation.) Work on angiogenesis inhibitors is at the vanguard. In a world worrying about whether it can afford health care, advances in prevention are at a premium.
Factoid: Cancers start as tiny nests of malignant cells that do not enlarge until they recruit new vessels to deliver oxygen and nutrients; then a cancer can expand 16,000 times in only two weeks.

こんなのも入っています。解ってるのかな本当に。
NYTではBonoは

Bono, the lead singer of the band U2 and a founder of the advocacy group ONE and (Product)RED, is a contributing columnist for The Times.

こんな風に紹介されていました。

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