hypoxia research::blog

平成21年05月31日現在

氏　名 広田　喜一　(ひろた　きいち)

現職

京都大学大学院医学研究科・侵襲反応制御医学講座・麻酔科学分野　講師

京都大学医学部附属病院麻酔科　副科長

京都大学医学部附属病院デイ・サージャーリー診療部　副部長

連絡先

〒606-8507

京都市左京区聖護院河原町54 第一臨床研究棟 324室

tel:075-751-3434 fax:075-752-3259

院内PHS: 2819

hif1@mac.com

学　歴

昭和57年4月01日 京都大学医学部医学科医学進学課程入学

昭和59年4月01日 京都大学医学部医学科専門課程進学

平成63年3月24日 同上卒業

平成04年4月01日 京都大学大学院医学研究科博士課程（外科系専攻）入学

平成08年3月23日 同上博士課程所定の単位修得及び研究指導認定

平成09年3月23日 博士(医学）京都大学

職　歴

昭和63年4月01日 京都大学医学部麻酔学教室において研究に従事

昭和63年6月01日 京都大学医学部附属病院（麻酔科 研修医）勤務

平成元年5月31日 同上退職

平成元年6月01日 滋賀県立成人病センター（麻酔科 医師）勤務

平成03年8月31日 同上退職

平成03年9月01日 大津市立大津市民病院（麻酔科 医師）勤務

平成03年8月31日 同上退職

平成08年4月01日 京都大学医学部附属病院（麻酔科 医員）勤務

平成08年5月31日 同上退職

平成08年6月01日 京都大学医学部附属病院 (麻酔科助手文部教官)勤務

平成11年8月15日 同上休職

平成11年8月16日 ジョンズホプキンス大学　医学部　客員教授

平成14年2月15日 京都大学医学部附属病院、ジョンズホプキンス大学　退職

平成14年2月17日 独立行政法人　産業技術総合研究所　主任研究員

平成14年5月01日 京都大学医学部非常勤講師併任-平成17年3月31日まで

平成15年8月31日 産業技術総合研究所 退職

平成15年9月01日 田附興風会医学研究所　北野病院　麻酔科-

平成17年3月31日 退職

平成17年4月01日 京都大学大学院医学研究科・侵襲反応制御医学講座・麻酔科学分野-講師

現在に至る

資　格

昭和63年5月17日 医師免許証取得（医籍登録番号 第311776号）

平成3年9月27日 麻酔科標榜許可-厚生省（麻第5743号）

平成4年7月14日 第一種放射線取扱主任者免状-科学技術庁(第13467号)

平成9年3月23日 博士（医学）（京都大学）

平成21年4月1日 日本麻酔学会指導医・専門医　(認定番号3973号)

論文リスト（2009年8月現在）
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1. Tanaka T, Takabuchi S, Nishi K, Oda S, Wakamatsu T, Daijo H, Fukuda K, Hirota K: The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible factor 1 activation and suppresses the glucose metabolism in macrophages. J Anesth In press

2. Hara Y, Hirota K, Fukuda K: Successful airway management with use of a laryngeal mask airway in a patient with CHARGE syndrome. J Anesth In press

3. Wakamatsu T, Tanaka T, Oda S, Nishi K, Harada H, Daijo H, Takabuchi S, Kai S, Fukuda K, Hirota K: The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation. Eur J Pharmacol 2009; 617: 17-22

4. Oda S, Oda T, Takabuchi S, Nishi K, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Nohara R, Hirota K: The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells. Eur J Pharmacol 2009; 606: 130-6

5. 広田　喜一, 田中　具治: 低酸素応答と低酸素センサー. Life Support and Anesthesia 2008; 15: 238-243

6. 広田　喜一: ハイポキシア生物学-酸素代謝からみる生命現象の方程式. 医学のあゆみ 2008; 225

7. Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K: Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS ONE 2008; 3: e2215

8. Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K: LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid Redox Signal 2008; 10: 983-96

9. Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K: n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. Biochem J 2008; 411: 97-105

10. 広田　喜一: 細胞の低酸素応答機構-低酸素センサーを巡る論争. 実験医学 2007; 25: 2120-2126

11. Umegaki T, Kikuchi O, Hirota K, Adachi T: Comparison of continuous intraarterial blood gas analysis and transcutaneous monitoring to measure oxygen partial pressure during one-lung ventilation. J Anesth 2007; 21: 110-1

12. Sommani P, Yamashita K, Miyoshi T, Tsunemine H, Kodaki T, Mori H, Hirota K, Arai T, Sasada M, Makino K: Inhibitory Effect of 6-Formylpterin on HIF-1alpha Protein Accumulation. Biol Pharm Bull 2007; 30: 2181-4

13. Li X, Kimura H, Hirota K, Sugimoto H, Kimura N, Takahashi N, Fujii H, Yoshida H: Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-g in human proximal renal tubular cells. Nephrol. Dial. Transplant. 2007; 22: 1041-1051

14. Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T: Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 2007; 67: 4157-63

15. Adachi T, Hirota K, Hara T, Sasaki Y, Hara Y: Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia. Anesth Analg 2007; 105: 696-9

16. 広田喜一: 低酸素センサー-細胞は低酸素をいかに関知するか-. Anesthesia Network 2006; 10: 11-15

17. Tsukiyama F, Nakai Y, Yoshida M, Tokuhara T, Hirota K, Sakai A, Hayashi H, Katsumata T: Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase. Biochem Biophys Res Commun 2006; 351: 234-9

18. Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R: Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol 2006; 291: C104-C113

19. Hirota K, Semenza GL: Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 2006; 59: 15-26

20. 季　軒, 木村　秀樹, 広田　喜一, 糟野　健司, 淀井　淳司, 吉田　治義: 腎間質線維化における低酸素と炎症性サイトカインの関与-特にPAI-1, TIMP-1動態の検討-. Pharma Medica 2005; 23: 97-99

21. Takabuchi S, Hirota K, Oda S, Nishi K, Oda T, Shingu K, Adachi T, Fukuda K: Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines. J Anesth 2005; 19: 263-265

22. Nishi K, Hirota K, Takabuchi S, Oda S, Fukuda K, Adachi T, Shingu K: The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1. J. Anesth. 2005; 19: 54-59

23. Li X, Kimura H, Hirota K, Sugimoto H, Yoshida H: Hypoxia reduces constitutive and TNF-a-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells. Biochem. Biophys. Res. Commun. 2005; 335: 1026-1034

24. Li X, Kimura H, Hirota K, Kasuno K, Torii K, Okada T, Kurooka H, Yokota Y, Yoshida H: Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells. Kidney Int. 2005; 68: 569-583

25. Hisano T, Namba T, Hashiguchi-Ikeda M, Itoh T, Hirota K, Fukuda K: Inhibition of E-selectin-mediated leukocyte adhesion by volatile anesthetics in a static condition. J. Anesth. 2005; 19: 1-6

26. Hirota K, Semenza G: Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun 2005; 338: 610-616

27. Hirota K, Hara T, Hosoi S, Sasaki Y, Hara Y, Adachi T: Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy. J. Anesth. 2005; 19: 75-77

28. 広田喜一: 低酸素応答の分子機構. Anesthesia 21 Century 2004; 6: 34-38

29. Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu T, Takabayashi A, Adachi T, Semenza GL, Fukuda K: The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner. FEBS Lett. 2004; 577: 434-438

30. Takabuchi S, Hirota K, Nishi K, Oda S, Oda T, Shingu T, Takabayashi A, Adachi T, Semenza GL, Fukuda K: The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide- soluble guanylyl cyclase pathway. Biochem. Biophys. Res. Commun. 2004; 324: 417-423

31. Nakamura H, Kondo N, Hirota K, Masutani H, Yodoi J: Thiols and thioredoxin in cellular redox control, Redox-genome interactions in health and disease. Edited by Fuchs J, Podda M, Packer L. New York, Marcel Dekker, Inc., 2004, pp 61-77

32. Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K: Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling. J Biol Chem 2004; 279: 2550-2558

33. Itoh T, Hirota K, Hisano T, Namba T, Fukuda K: The volatile anesthetics halothane and isoflurane differentially modulate pro-inflammatory cytokines-induced p38 mitogen-activated protein kinase activation. J. Anesth. 2004; 18: 203-209

34. Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL: Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J. Biol. Chem. 2004; 279: 41521-41528

35. Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Scholer H, Ramsey H, Hromas R: Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells 2004; 22: 259-264

36. Kelly B, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL: Cell-Type-Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Non-Ischemic Tissue by a Constitutively-Active Form of Hypoxia-Inducible Factor 1. Circ. Res. 2003; 93: 1074-1081

37. Matsuo Y, Hirota K, Nakamura H, Yodoi J: Redox regulation by thioredoxin and its related molecules. Drug News & Perspective 2002; 15: 575-580

38. Karimpour S, Lou J, Lin LL, Rene LM, Lagunas L, Ma X, Karra S, Bradbury CM, Markovina S, Goswami PC, Spitz DR, Hirota K, Kalvakolanu DV, Yodoi J, Gius D: Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene 2002; 21: 6317-6327

39. Hirota K, Nakamura H, Masutani H, Yodoi J: Thioredoxin superfamily and thioredoxin-inducing agents. Ann N Y Acad Sci 2002; 957: 189-99

40. Hirota K: Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression. J Anesth 2002; 16: 150-9

41. Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277: 38205-11

42. Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell P, Stockton DW, Semenza GL, Prchal JT: Disruption of oxygen homeostais underlines congenital Chuvash polycythemia. Nature Genetics 2002; 32: 614-621

43. Mahon PC, Hirota K, Semenza GL: FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes. Dev. 2001; 15: 2675-2686

44. Itoh T, Namba T, Fukuda K, Semenza GL, Hirota K: Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane. FEBS Lett. 2001; 509: 225-229

45. Hirota K, Semenza GL: Small GTPase protein Rac1 plays an essential role in hypoxia-inducible factor 1 activation in hypoxia. J. Biol. Chem. 2001; 276: 21166-21172

46. Hirota K, Murata M, Itoh T, Yodoi J, Fukuda K: An endogenous redox molecules, thioredoxin regulates signalling pathway of the NF-kB activation by lysophosphatidic acid. FEBS Lett. 2001; 489: 134-138

47. Hirota K, Murata M, Itoh T, Yodoi J, Fukuda K: Redox-sensitive transactivation of epidermal growth factor receptor by tumor necrosis factor confers the NF-κB activation. J. Biol. Chem. 2001; 276: 25953-25958

48. Arai T, Endo N, Yamashita K, Sasada M, Mori H, Ishii H, Hirota K, Makino K, Fukuda K: 6-Formylpterin, a xanthine oxidase inhibitor, intracellulary generates reactive oxigen species involved in apoptosis and cell proliferation. Free Redical Biol. Med. 2001; 30: 248-259

49. Wei SJ, Botero A, Hirota K, Bradbury CM, Markovina S, Laszlo A, Spitz DR, Goswami PC, Yodoi J, Gius D: Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer Res. 2000; 60: 6688-6695

50. Takeuchi J, Hirota K, Itoh T, Shinkura R, Kitada K, Yodoi J, Namba T, Fukuda K: Thioredoxin inhibits tumor necrosis factor- or interleukin-1-induced NF-kappaB activation at a level upstream of NF-kappaB-inducing kinase. Antioxid Redox Signal 2000; 2: 83-92

51. Namba T, Ishii TM, Ikeda M, Hisano T, Itoh T, Hirota K, Adelman JP, Fukuda K: Inhibition of the human intermediate conductance Ca(2+)-activated K(+) channel, hIK1, by volatile anesthetics. Eur. J. Pharmacol. 2000; 395: 95-101

52. Mori H, Arai T, Hirota K, Ishii H, Endo N, Makino K, Fukuda K: Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macropahages. Biochim. Biophys. Acta 2000; 1474: 93-99

53. Hirota K, Nakamura H, Arai T, Ishii H, Bai J, Itoh T, Fukuda K, Yodoi J: Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes. Biochem Biophys Res Commun 2000; 275: 825-30

54. Hirota K, Matsui M, Murata M, Takashima Y, Chen FS, Itoh T, Fukuda K, Yodoi J: Nucleoredoxin, Glutaredoxin, and Thioredoxin differentially regulate NF-κB, AP-1, and CREB activation in HEK293 cells. Biochem. Biophys. Res. Commun. 2000; 274: 177-182

55. Dekigai H, Nakamura H, Bai J, Tanito M, Masutani H, Hirota K, Matsui H, Murakami M, Yodoi J: Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and periferal blood lymphocytes. Free Rad. Res. 2000; 35: 1-8

56. 広田　喜一: リン酸化シグナルとレドックスシグナルのクロストーク（生体応答学の新展開）. 医学のあゆみ 1999: 179-183

57. Ueno M, Masutani H, Arai R, Yamauchi A, Hirota K, Sakai T, Inamoto T, Yamaoka Y, Yodoi J, Nikaido T: Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J. Biol. Chem. 1999; 274: 35809-35815

58. Tanaka T, Nishiyama Y, Okada K, Hirota K, Matsui M, Yodoi J, Hiai H, Yodoi J: Protective action of Adult T-Cell Leukemia-derived factor(ADF)/Thioredoxin(TRX) against oxidative damage in the kidney of mice treated with a renal carcinogen, Ferric Nitrilotriacetate: Induction and Nuclear Translocation of ADF/TRX., Redox Regulation of Cell Signaling and its Clinical Applivcation. Edited by Packer L, Yodoi J. New York, Marcel Dekker, Inc., 1999

59. Takashima Y, Hirota K, Nakamura H, Nakamura T, Akiyama K, Chen F-S, Maeda M, Yodoi J: Differential expression of glutaredoxin and thioredoxin during monocytic differentiation. Immunol. Lett. 1999; 68: 397 – 401

60. Ohno T, Akamatsu K, Hirota K, Kagoshima H, Shitgesada K, Yodoi J: Redox regulation of DNA-binding activity in transcription factor PEBP2., Redox Regulation of Cell Signaling and its Clinical Applivcation. Edited by Packer L, Yodoi J. New York, Marcel Dekker, Inc., 1999

61. Nishiyama A, Ohno T, Iwata S, Matsui M, Hirota K, Masutani H, Nakamura H, Yodoi J: Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system. Immunol Lett 1999; 68: 155-9

62. Nishiyama A, Iwata S, Matsui M, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J: Identification of thioredoxin binding protein-2/vitamin D3 up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J. Biol. Chem. 1999; 274: 21645-21650

63. Nakamura T, Ohno T, Hirota K, Nishiyama A, Nakamura H, Wada H, Yodoi J: Mouse glutaredoxin- cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2. Free Radical Res. 1999; 4: 357-365

64. Hirota K, Nishiyama A, Yodoi J: Reactive oxygen intermediates, thioredoxin, and Ref-1 as effector molecules incellular signal transduction. Tanpakushitsu Kakusan Koso 1999; 44: 2414-2419

65. Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, Yodoi J: Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus: A Two Step Mechanism of Redox Regulation of Transcription Factor NF-kB. J. Biol. Chem. 1999; 274: 27891-27897

66. Hirota K, Mastui M, Iwata S, Nishiyama A, Yodoi J: AP-1 transcriptional activity regulated by a direct association between thioredoxin and Ref-1., Redox Regulation of Cell Signaling and its Clinical Applivcation. Edited by Packer L, Yodoi J. New York, Marcel Dekker, Inc., 1999

67. Hashimoto S, Matsumoto K, Gon Y, Furuichi S, Maruoka S, Takeshita I, Hirota K, Yodoi J, Horie T: Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-alpha. Biochem Biophys Res Commun. 1999; 258: 443-447

68. Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y: Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999; 18: 1905-14

69. Yodoi J, Nishiyama A, Oono T, Hirota K, Masutani H: Thioredoxin target molecules in redox signal cascade. Pathophysiology 1998; 5: 92

70. Tanaka H, Makino Y, Okamoto K, Hirota K, Yodoi J, Ogawa H, Umesono K, Makino I: Redox regulation of glucocorticoid receptor. Pathophysiology 1998; 5: 92

71. Makino Y, Yoshikawa N, Okamoto K, Hirota K, Yodoi J, Makino I, Tanaka H: Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function. J. Biol. Chem. 1998; 274: 3182-3188

72. Yamaguchi R, Mazaki Y, Hirota K, Hashimoto S, H. S: Mitosis specific serine phosphorylation and downregulation of one of the focal adhesion proteins, paxillin. Oncogene 1997; 15: 1753

73. Tanaka T, Nishiyama Y, Okada K, Hirota K, Matsui M, Yodoi J, Hiai H, Toyokuni S: Induction and Nuclear Transloction of Thioredoxin by Oxidative Damage in the Mouse Kidney: Independence of Tubular Necrosis and Sulfhydryl Depletion. Lab. Invest. 1997; 77: 145-155

74. Ohno T, Hirota K, Nakamura H, Masutani H, Sasada T, Yodoi J: Thioredoxin and its involvement in the redox regulation of transcription factors, NF-kB and AP-1. Keio university synposia for life science and medicine 1997; 1: 450-456

75. Nishiyama A, Furuke K, Hirota K, Masutani H, Yodoi J: Detection of a nuclear 60-kDa protein coimminoprecipitates with human thiordoxin. Keio university synposia for life science and medicine 1997; 1997: 464-468

76. Maruyama T, Kitaoka Y, Sachi Y, Nakanoin K, Hirota K, Shiozawa T, Yoshimura Y, Fujii S, Yodoi J: Thioredoxin expression in the human endometrium during the menstrual cycle. Mol Hum Reprod 1997; 3: 989-93

77. Iwata S, Hori T, Sato N, Hirota K, Sasada T, Mitsui A, Hirakawa T, Yodoi J: Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state. J Immunol 1997; 158: 3108-3117

78. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J: AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. U S A. 1997; 94: 3633-3638

79. Akamatsu Y, Ohno T, Hirota K, Kagoshima H, Yodoi J, Shigesada K: Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues. J. Biol. Chem. 1997; 272: 14497-14500

80. Sasada T, Iwata S, Sato N, Kitaoka Y, Hirota K, Nakamura K, Nishiyama A, Taniguchi Y, Takabayashi A, Yodoi J: Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity. J. Clin. Invest. 1996; 97: 2268-2276

81. Masutani H, Hirota K, Sasada T, Ueda Taniguchi Y, Taniguchi Y, Sono H, Yodoi J: Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax. Immunol Lett 1996; 54: 67-71

82. Makino Y, Okamoto K, Yoshikawa N, Aoshima M, Hirota K, Yodoi J, Umesono K, Makino I, Tanaka H: Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system. J. Clin. Invest. 1996; 98: 2469-2477

83. 広田　喜一, 豊国　伸哉, 淀井　淳司: レドックス反応の起源と進化. 科学(岩波書店） 1995; 65: 537-545

84. Sachi Y, Hirota K, Masutani H, Toda K-i, Okamoto T, Takigawa M, Yodoi J: Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells. Immunol. Letter 1995; 44: 189-193

85. Matsui M, Taniguchi Y, Hirota K, Taketo M, Yodoi J: Structure of the mouse thioredoxin-encoding gene and its processed pseudogene. Gene 1995; 152: 165-71 Issn: 0378-1119

86. Morikawa H, Hirota K, Kito K, Fujita H, Mishima S: Re-expansion pulmonary oedema following removal of intrathoracic haematoma. Acta Anaesthesiol Scand 1994; 38: 518-520

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